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Daniel Alexa

Latest posts by Daniel Alexa (see all)

  • THE ROLE OF RIGHT HEMISPHERE IN RECOVERY OF POST-STROKE APHASIA - 20/10/2016
  • BRAINSTEM AUDITORY EVOKED POTENTIALS IN PARKINSON’S DISEASE - 07/01/2016
  • ANKYLOSING SPONDYLITIS AND MULTIPLE SCLEROSIS: A SURPRISING PARALLEL - 15/09/2015

Articles signed on Romanian Journal of NEUROLOGY:

THE ROLE OF RIGHT HEMISPHERE IN RECOVERY OF POST-STROKE APHASIA

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Romanian Journal of Neurology, Volume XV, No. 2, 2016
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

THE ROLE OF RIGHT HEMISPHERE IN RECOVERY OF POST-STROKE APHASIA

Adriana Elena Nica, Dan Nicolae Paduraru, Daniel Alexa, Octavian Andronic and Tabita Cazac

ABSTRACT

Previous data obtained especially from rTMS studies indicate that right hemisphere recruitment has a limiting effect on recovery of poststroke aphasia in right handed patients by inhibiting the activation of intact perilesional areas in left hemisphere and preventing them from regaining function. New researches bring new arguments to support the positive influence of right hemisphere on restoration of language and communication. In this paper we try to review the latest evidences regarding the contribution of the right hemisphere to post-stroke aphasia recovery.

Keywords: aphasia, right hemisphere, right temporoparietal regions

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BRAINSTEM AUDITORY EVOKED POTENTIALS IN PARKINSON’S DISEASE

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Romanian Journal of Neurology, Volume XII, No. 4, 2013
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

BRAINSTEM AUDITORY EVOKED POTENTIALS IN PARKINSON’S DISEASE

Daniel Alexa, Laura Alexa, Livia Popa, Dan Nicolae Paduraru, Bogdan Ignat, Aurora Constantinescu, Doru Baltag, Alexandrina Rotar and Cristian Dinu Popescu

ABSTRACT

Background. Parkinson’s disease is a neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra, but also in other dopaminergic and nondopaminergic areas of the brain and mainly in the brainstem. Auditory evoked potentials are routinely used in clinical practice to evaluate the function of the auditory nerve and auditory pathways in the brainstem. The aim of this study was to investigate the auditory brainstem pathways in patients with Parkinson disease.

Materials and methods. In this study was included 34 patients with Parkinson’s disease. The control group was composed of 29 healthy age- and sex-matched subjects. Detailed examination were performed in all individuals and the parkinsonian patients were stage between 2 and 4 according to Hoehn and Yahr’s classication. Recordings of BAEPs were performed with Nihon Kohden Neuropack using 80 dB HL alternating polarity clicks in each ear at a rate of 10 s-1.. Averaged potentials to 1,000 clicks were obtained.

Results. The BAEP results were interpreted for the latencies of waves I, II, III, IV, V and Interpeak Latencies (IPL) I-III, III-V and I-V. The results of our study have shown that the waves II, III, IV, V and IPL III-V were significantly delayed bilaterally. This modifications does not correlates with the age or duration of disease

Conclusion. This study showed some modifications of auditory evoked potentials wich can be determined by the neurodegenerative process that affects the brainstem.

Keywords: Parkinson disease, auditory evoked potentials, auditory pathways

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ANKYLOSING SPONDYLITIS AND MULTIPLE SCLEROSIS: A SURPRISING PARALLEL

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Romanian Journal of Neurology, Volume XIII, No. 3, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ANKYLOSING SPONDYLITIS AND MULTIPLE SCLEROSIS: A SURPRISING PARALLEL

Iulia Georgiana Stamate, Daniel Alexa, Bogdan Ignat and Cristian Dinu Popescu

ABSTRACT

Ankylosing Spondylitis (AS) and Multiple Sclerosis (MS) are two different chronic autoimmune and inflammatory diseases, one rheumatic and the other one neurological, apparently without any connection between them. Yet a few case reports proved that AS may be associated with MS and this situation should be considered in some epidemiological environment.

Although the geographic map of incidence is approximately superposed for both entities there are only a few cases of association. Recent studies revealed that most loci associated with MS are located very close to or even within genes encoding molecules involved in immune system function, confirming the hypothesis that MS is a disease with immunologic mechanism. In addition, some of these loci are also associated at least with another autoimmune disease, thus reinforcing the idea that autoimmune diseases may have a common origin.

If MS is more common in patients with AS than in the general population, we can speculate the existence of common factors involved in these diseases. Because of the limited number of cases that associated these two diseases, the correct diagnosis of both entities considered separately or together becomes mandatory especially reflecting on the anti-TNFα agents used to treat AS which may exacerbate or induce a latent MS or demyelination processes in the central nervous system. In terms of pathogenic mechanisms, they are poorly known in both diseases, but each is characterized by an initial immune and inflammatory attack, in MS the target is the myelin sheath and in AS the enthesis tissue. A case with association between the two diseases raises important issues in choosing an appropriate treatment.

Keywords: ankylosing spondylitis, multiple sclerosis, autoimmune disease, TNFα

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SOCIO-ECONOMIC ISSUES IN ALZHEIMER’S DISEASE. RESILIENCE AND ALZHEIMER’S DISEASE CAREGIVERS

SELECT ISSUE

Romanian Journal of Neurology, Volume XIII, No. 4, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

SOCIO-ECONOMIC ISSUES IN ALZHEIMER’S DISEASE. RESILIENCE AND ALZHEIMER’S DISEASE CAREGIVERS

Cristian Dinu Popescu, Dan Trofin, Daniela Trofin, Daniel Alexa, Romeo Dobrin, Bogdan Ignat, Ioan Buraga and Daniela Matei

ABSTRACT

Alzheimer’s Disease (AD) is the most common form of dementia in the old population, carrying a major negative influence upon society and caregivers, as its socio-economic implications are enormous. The devastating impact of AD is also due to the fact that the diagnosis is difficult to be established in an early stage, and in spite of the advances made in medicine, the new symptomatic and disease modifying therapies have still only a mild though promising positive effect. Caregivers are exposed to increased risk of disease themselves, due to the high burden which predisposes them to stress related psychological, behavioral or cognitive disorders. Greater caregiver resilience can predict lower levels of depression. Also a strong external support system was associated with increased resilience. Establishing a pattern for the behavioral and psychological manifestations in dementia can have as direct effect developing better coping strategies in order to reduce stress and the burden of the caregivers.

Some data regarding the economic and social impact of AD, as well as facts and numbers from our local centers will be described in the following pages.

Keywords: dementia, Alzheimer’s Disease, social, economics, caregiver, burden

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