Ioan Buraga

Latest posts by Ioan Buraga (see all)

THREE CASE SERIES INVOLVING PROGRESIVE MOTOR DEFICIT - 27/01/2017
CHIARI MALFORMATION TYPE I – CASE REPORT AND REVIEW OF LITERATURE - 31/10/2016
BRAIN MRI FINDINGS IN ACUTE HYPERAMMONEMIC ENCEPHALOPATHY SECONDARY TO ISCHEMIC HEPATITIS: CASE REPORT AND REVIEW OF THE LITERATURE - 26/04/2016

Articles signed on Romanian Journal of NEUROLOGY:

THREE CASE SERIES INVOLVING PROGRESIVE MOTOR DEFICIT

Romanian Journal of Neurology, Volume XV, No. 4, 2016

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Bogdan Pana, Alina Anghel, Iuliana Nicola-Antoniu and Ioan Buraga

ABSTRACT

The muscular dystrophyes are a group of inherited, non-inflamatory disorders, consisting of progresive muscle wasting, without perripheral or central nerve involvement. We present a series of three cases involving progresive motor deficit and their different evolutions. The first case is about a 57 year old female patient, without a significant family medical history, presenting for progresive motor deficit involving the shoulder and pelvic muscles, started at the age of 20 year old, when she was diagnosed with a sporadic form of limb-girdle muscular dystrophy. The second case is about a 27 year old male, diagnosed with muscular dystrophy at the age of 15. The third case is about a 43 year old male admitted for frequent falls and weakness of the limbs, mainly distal, started 10 years ago. He was diagnosed with myotonic dystrophy. Although there is still no treatment for muscular dystrophies, the pathology is under investigation in clinical trials.

Keywords: fetal stroke, alloimmune/autoimune thrombocytopenia, intracranial hemorrhage, neurological consequences

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CHIARI MALFORMATION TYPE I – CASE REPORT AND REVIEW OF LITERATURE

Romanian Journal of Neurology, Volume XV, No. 3, 2016

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

ICMJE- Recommendations

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Promoting Global Health

Ioana Cociasu, Mihnea Pastia, Irene Davidescu, Ioan Buraga and Bogdan O. Popescu

ABSTRACT

Chiari malformations are congenital defects involving the cerebral structures in the posterior fossa. They range from asymptomatic cerebellar tonsil herniation beside the brainstem, to cerebellar aplasia. These conditions were first described in 1890 and are still considered a rare occurrence even though they are more likely under-diagnosed rather than rare. We report the case of a 44 year old woman with Chiari type I malformation and associated cervical syringomyelia.

Keywords: type I, syringomyelia, syrinx, Arnold-Chiari, headache, tonsil herniation, congenital

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BRAIN MRI FINDINGS IN ACUTE HYPERAMMONEMIC ENCEPHALOPATHY SECONDARY TO ISCHEMIC HEPATITIS: CASE REPORT AND REVIEW OF THE LITERATURE

Romanian Journal of Neurology, Volume XV, No. 1, 2016

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

ICMJE- Recommendations

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Promoting Global Health

Ana-Maria Vladila, Dan-Andrei Mitrea, Sanda Nica, Gabriela Mihailescu and Ioan Buraga

ABSTRACT

Acute encephalopathy is frequently seen in Neurology and Internal Medicine Departments, it makes for a wide spectrum of neuropsychiatric abnormalities, but its brain magnetic resonance imaging appearance in the adult population is not well recognised.
We present the case of an acute hyperammonemic encephalopathy in the setting of ischemic hepatitis secondary to global heart failure and its MRI findings with a review of the literature.

Keywords: acute hepatic encephalopathy, hyperammonemia, ischemic hepatitits, insular cortex, FLAIR hypersignal, restriction of diffusion

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RECURRENT MENINGIOMA AFTER INITIAL RESECTION SURGERY – CASE REPORT

Romanian Journal of Neurology, Volume XIV, No. 4, 2015

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

ICMJE- Recommendations

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Promoting Global Health

Ioana Cociasu, Irene Davidescu, Ioan Buraga and Bogdan O. Popescu

ABSTRACT

The most common tumours of the central nervous system, meningiomas are frequently diagnosed by accident when patients undergo imaging studies of the brain for other reasons. Most patients lack symptoms and thus can live their whole lives without knowing they have a brain tumour. Less fortunate patients seek medical advice for troubling symptoms – like seizures or disturbances of the cranial nerves – get surgery for the excision of the tumour and years later find out their tumour has come back. We are presenting the case of such a patient with a recurrent parietal meningioma.

Keywords: meningioma, multiple meningiomas, recurrent meningioma, seizures, radiotherapy

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PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY ASSOCIATED TO MULTIPLE SCLEROSIS THERAPIES: REVIEW OF THE LITERATURE

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

ICMJE- Recommendations

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Ana-Maria Vladila, Dan-Andrei Mitrea, Sanda Maria Nica and Ioan Buraga

ABSTRACT

Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection associated with the reactivation of the JC virus, causing a severe demyelination within the central nervous system in patients with immunosuppression caused by disease or secondary to use of drugs. Several therapies used in the treatment of MS have reported cases of associated PML, most cases being related to Natalizumab treatment. In this article we review specific MS medication with a reported risk for PML, and also revise PML epidemiology, pathogenesis, treatment and available approaches on therapy in patients at high risk for developing this infection.

Keywords: PML, JC virus, multiple sclerosis, Natalizumab, Fingolimod, dimethyl fumarate, alemtuzamab, PCR, cerebral MRI demyelinating lesion, plasma exchange, Mirtazapine

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NEUROCOGNITIVE DISORDER AND DYSGENESIS OF CORPUS CALLOSUM

Romanian Journal of Neurology, Volume XII, No. 4, 2013

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

Irene Davidescu, Ruxandra Maria Anton, Gabriela Mihailescu, Delia Parvu, Sanda Maria Nica, Ioan Buraga and Bogdan O. Popescu

ABSTRACT

We report the case of a 68 year-old female (O.F.), referred to our clinic for a neurological evaluation after an episode of loss of consciousness that occurred three days before admittance. She was also diagnosed with cognitive impairment (July 2011). Case particularity: the MRI examination, which was the investigation of choice in this case, revealed structural brain abnormalities – dysgenesis of the corpus callosum

Keywords: corpus callosum, MRI, neurocognitive disorder

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MULTIPLE CEREBRAL CAVERNOUS MALFORMATIONS – A CASE REPORT

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Ana-Maria Vladila, Georgiana Pavel, Dan Mitrea, Sanda Nica, Gabriela Mihailescu, Irene Davidescu and Ioan Buraga

ABSTRACT

Cavernomas are frequent low-flow vascular malformations with a characteristic MRI aspect due to their specific morphology. We present the case of a 64-year old male diagnosed in 2008 with multiple cerebral cavernomas and symptomatic epilepsy, who developed left face, arm and leg paresthesias during the last 6 days. The MRI examination performed in our clinic showed increased number of infracentimetic lesions with no signs of hemorrhage or growth of the previous documented ones. Considering MRI findings and the patient being seizure free for the last three years there is no current indication for invasive treatment. The presence of multiple lesions along with their aspect on T2* MRI sequences suggest a hereditary form in absence of familial history of cerebral cavernous malformations.

Keywords: multiple cerebral cavernomas, symptomatic epilepsy, MRI T2*

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VITAMIN D INTOXICATION IN A PATIENT WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS – CASE REPORT

Romanian Journal of Neurology, Volume XIV, No. 3, 2015

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

ICMJE- Recommendations

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Promoting Global Health

Ioana Cociasu, Irene Davidescu, Ioan Buraga and Bogdan Ovidiu Popescu

ABSTRACT

Lately, vitamin D has been a hot topic among multiple sclerosis specialists. Vitamin D supplementation is being thoroughly researched in order to establish whether or not it is useful in the treatment of multiple sclerosis. We present the case of a patient with multiple sclerosis, who, after searching online, decided to administer vitamin D supplements in high doses; subsequently he was admitted to our for clinic symptoms consistent with vitamin D intoxication.

Keywords: vitamin D, toxicity, multiple sclerosis, relapsing-remitting

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CHRONIC SUBDURAL HEMATOMA: A CASE REPORT AND REVIEW OF THE LITERATURE

Romanian Journal of Neurology, Volume XIII, No. 1, 2014

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

Ana-Maria Vladila, Dan-Andrei Mitrea, Sanda Nica, Georgiana Pavel, Gabriela Mihailescu, Ioan Buraga and Doru Baltateanu

ABSTRACT

Chronic subdural hematoma is a common type of intracranial hemorrhage with higher incidence and unpredictable evolution among elderly people. We present the case of a 73 years old male patient, diagnosed in October 2013 with subacute bilateral subdural hematomas who was admitted in our clinic for worsening of motor function in his left limbs. The cerebral CT performed revealed a right massive chronic subdural hematoma which met the criteria for neurosurgical approach requiring a large craniotomy for complete removal. In this article we review the risk factors associated with an unpredictable evolution and postoperative subdural hematoma recurrence in the elderly.

Keywords: chronic subdural hematoma, elderly, epilepsy, atrial fibrillation, antiplatelet/ anticoagulant medication, large craniotomy, bleeding, subdural hematoma recurrence

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NEUROFIBROMATOSIS – CASE PRESENTATION

ISSN 1843-8148 | e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Ioan Buraga, Daniela Trasca, Mihaela Selescu, Cristina Baetu, Oana Milea and Adelina Serban

ABSTRACT

We are presenting the case of a 43 year old man, without significant phatological antecedents, who accused back pain with irradiation on the back of the thigh and the right calf, which were associated with paresthesia at the same level. Symptoms appeared a year ago, when the patient was on symptomatic treatments with minimal results.

On the generally examination there are found fifteen café au lait spots, distributed on the torso and limbs with the diameter above 15 mm, axillary hyperpigmentation, ten cutaneous neurofibromas with the same distribution and Lisch nodules in the iris.

We proceeded to MRI examination of the lumbar spine that reveals an important irregular thickening, tortue with pseudotumoral aspect, predominantly in the extraforamenal and periferic path and less in the intraforamenal of nerve roots from T12 to the sacral roots; widening of the conjugation foramina; changes are more pronounced in the sacral plexus (left > right), the terminal segments presenting the appearance of „pelvic mass“ – MRI compatible with plexiform neurofibromas aspect. The final step was the histopatological examination which confirmed the diagnostic. The particularity of this case is that this pacient was very late diagnosed, despite the fact that he had many pathognomonical elements of neurofibromatosis, and his simptomatology was rough, ussualy this disease is diagnosed in childhood or as an young adult.

Keywords: café au lait, Lisch nodules, neurofibromas

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