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Bogdan O. Popescu

Latest posts by Bogdan O. Popescu (see all)

  • CHIARI MALFORMATION TYPE I – CASE REPORT AND REVIEW OF LITERATURE - 31/10/2016
  • A THREE-STEP EXAMINATION IN DIFFERENTIATING PERIPHERAL FROM CENTRAL VERTIGO - 26/04/2016
  • THE PSEUDOSCLEROTIC FORM (“WING-BEATING TREMOR”) OF WILSON’S DISEASE - 21/01/2016

Articles signed on Romanian Journal of NEUROLOGY:

CHIARI MALFORMATION TYPE I – CASE REPORT AND REVIEW OF LITERATURE

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Romanian Journal of Neurology, Volume XV, No. 3, 2016
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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CHIARI MALFORMATION TYPE I – CASE REPORT AND REVIEW OF LITERATURE

Ioana Cociasu, Mihnea Pastia, Irene Davidescu, Ioan Buraga and Bogdan O. Popescu

 ABSTRACT

Chiari malformations are congenital defects involving the cerebral structures in the posterior fossa. They range from asymptomatic cerebellar tonsil herniation beside the brainstem, to cerebellar aplasia. These conditions were first described in 1890 and are still considered a rare occurrence even though they are more likely under-diagnosed rather than rare. We report the case of a 44 year old woman with Chiari type I malformation and associated cervical syringomyelia.

Keywords: type I, syringomyelia, syrinx, Arnold-Chiari, headache, tonsil herniation, congenital

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A THREE-STEP EXAMINATION IN DIFFERENTIATING PERIPHERAL FROM CENTRAL VERTIGO

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Romanian Journal of Neurology, Volume XV, No. 1, 2016
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

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A THREE-STEP EXAMINATION IN DIFFERENTIATING PERIPHERAL FROM CENTRAL VERTIGO

Irina Orban, Laura Dumitrescu, Bogdan O. Popescu and Radu Tanasescu

 INTRODUCTION

Dizziness is the reason of 10% of emergency department visits (1). The asssessment of acute balance problems and vertigo in the A&E setting or on the ward is often a challenge to the young neurologist. The ideal test to differentiate central from peripheral vertigo should be straightforward, cheap and with both good sensitivity and specificity. What best than a clinical series of tests easy to be performed at the bedside and able to replace brain MRI, when assessing a vestibular syndrome in the acute phase? 

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THE PSEUDOSCLEROTIC FORM (“WING-BEATING TREMOR”) OF WILSON’S DISEASE

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Romanian Journal of Neurology, Volume XIV, No. 4, 2015
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

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THE PSEUDOSCLEROTIC FORM (“WING-BEATING TREMOR”) OF WILSON’S DISEASE

Alina Poalelungi, Viorel Poalelungi, Daniela Mladin and Bogdan O. Popescu

ABSTRACT

Wilson disease is a rare monogenic, autosomal recessive disorder of copper metabolism, leading to progressive accumulation of copper in different organs, essentially in the liver, brain and cornea. We report a case of a 25 years old man, Caucasian, with “wing-beating tremor” in the right arm that started with two month in advance of hospital admission, than evolved to the left arm, a week before hospitalization. The slit-lamp examination showed the presence of Kayser-Fleischer rings in both eyes. The laboratory tests and brain MRI confirmed the diagnostic of Wilson’s disease.

Keywords: Wilson disease, copper metabolism, wing-beating tremor

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RECURRENT MENINGIOMA AFTER INITIAL RESECTION SURGERY – CASE REPORT

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Romanian Journal of Neurology, Volume XIV, No. 4, 2015
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

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RECURRENT MENINGIOMA AFTER INITIAL RESECTION SURGERY – CASE REPORT

Ioana Cociasu, Irene Davidescu, Ioan Buraga and Bogdan O. Popescu

ABSTRACT

The most common tumours of the central nervous system, meningiomas are frequently diagnosed by accident when patients undergo imaging studies of the brain for other reasons. Most patients lack symptoms and thus can live their whole lives without knowing they have a brain tumour. Less fortunate patients seek medical advice for troubling symptoms – like seizures or disturbances of the cranial nerves – get surgery for the excision of the tumour and years later find out their tumour has come back. We are presenting the case of such a patient with a recurrent parietal meningioma.

Keywords: meningioma, multiple meningiomas, recurrent meningioma, seizures, radiotherapy

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NEUROCOGNITIVE DISORDER AND DYSGENESIS OF CORPUS CALLOSUM

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Romanian Journal of Neurology, Volume XII, No. 4, 2013
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

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NEUROCOGNITIVE DISORDER AND DYSGENESIS OF CORPUS CALLOSUM

Irene Davidescu, Ruxandra Maria Anton, Gabriela Mihailescu, Delia Parvu, Sanda Maria Nica, Ioan Buraga and Bogdan O. Popescu

ABSTRACT

We report the case of a 68 year-old female (O.F.), referred to our clinic for a neurological evaluation after an episode of loss of consciousness that occurred three days before admittance. She was also diagnosed with cognitive impairment (July 2011). Case particularity: the MRI examination, which was the investigation of choice in this case, revealed structural brain abnormalities – dysgenesis of the corpus callosum

Keywords: corpus callosum, MRI, neurocognitive disorder

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RIGHT TRANSVERSE SINUS THROMBOSIS AND BILATERAL PCA STROKE IN A PATIENT WITH A HYPERCOAGULABLE STATE

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Romanian Journal of Neurology, Volume XII, No. 4, 2013
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

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RIGHT TRANSVERSE SINUS THROMBOSIS AND BILATERAL PCA STROKE IN A PATIENT WITH A HYPERCOAGULABLE STATE

Georgiana Mares, Alexandra Oprisan, Delia Parvu and Bogdan O. Popescu

ABSTRACT

Essential thrombocythosis (ET) is a myeloproliferative disorder (MPD) associated with an increase number of circulating platelets due to megakaryocyte proliferation. We report on a 72 years old man who was admitted in our department for headache and visual impairment. Brain imaging revealed bilateral occipital infarction and right transverse sinus thrombosis. The patient had common cardiovascular risk factors, recurrent deep vein thrombosis and sustained elevation of platelet counts in the past 8 years.

Keywords: cerebral venous thrombosis, occipital stroke, thrombocytosis, essential thrombocythemia, myeloprolipherative disorder, hypercoagulable state

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DYNAMICS OF ENDOTHELIN LEVELS IN MUSCLE REGENERATION AFTER MECHANICAL TRAUMA

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Romanian Journal of Neurology, Volume XIV, No. 3, 2015
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

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DYNAMICS OF ENDOTHELIN LEVELS IN MUSCLE REGENERATION AFTER MECHANICAL TRAUMA

Laura Cristina Ceafalan, Emilia Manole, Cristiana Pistol Tanase, Elena Codrici, Simona Mihai and Bogdan O. Popescu

ABSTRACT

Objectives. Muscle regeneration after trauma is a complex phenomenon involving several cellular processes, such as angiogenesis, inflammation, fibrosis, activation of satellite cells and their differentiation into myocytes and myotubes. Although many studies explored these mechanisms in the last years, there is still an unmet need to find new therapy targets, especially regarding some cellular molecules involved in muscular recovery after mechanical or pathological injury. In the present study we investigated the dynamics of endothelin-1 (ET-1), an important factor that has been shown to be involved in all stages of tissue regeneration, but which is poorly investigated in skeletal muscle.
Materials and methods. We used an experimental animal model of acute mechanical trauma on mouse gastrocnemius muscle. ET-1 levels were investigated at different time-points after muscle injury by in situ immunofluorescence, xMAP assay on tissue and serum samples, and Western Blot analysis.
Results. By xMAP assay, tissue ET-1 levels increased significantly up to the 5th day after trauma, correlated with serum levels. xMAP assay was confirmed by Western blot analysis which showed a significant increase in the level of ET-1 towards the end of the first week after trauma. This corresponds with the inflammatory stage of the regeneration process, followed by angiogenesis and satellite cell activation. In situ immunostaining showed a multiplication of interstitial cells expressing ET-1 in the first week after muscle injury. Two cellular subtypes were detected in the connective tissue – one is represented by blood-derived CD45 positive cells and the other by local interstitial cells. Such cells were detected in all connective tissue compartments, in close association with CD56 positive satellite cells, myoblasts and myotubes and most of them co-express sca-1.
Conclusions. The present study demonstrated that ET-1 is synthesized mostly by mesenchymal progenitors and their number greatly increases after mechanical trauma in muscle interstitium. Based on ET-1 expression and their close association with activated satellite cells, such cells could have a paracrine influence not only over angiogenesis but also over fiber regeneration. ET-1 appears as an important molecule working in conjunction with other various signalling pathways especially during first stages of the regeneration process after acute mechanical injury. ET-1 and its receptors could become therapeutic targets, especially for inflammatory myopathies and muscular dystrophies with significant pathological fibrosis.

Keywords: endothelin, skeletal muscle mechanical trauma, muscle regeneration, angiogenesis, inflammation, satellite cells, fibrosis

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CREUZFELDT-JAKOB’S DISEASE – CASE REPORT

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Romanian Journal of Neurology, Volume XIII, No. 1, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

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CREUZFELDT-JAKOB’S DISEASE – CASE REPORT

Z. Cofoian-Amet, B. Rusu, C. Mitu, E. Roşianu and Bogdan O. Popescu

ABSTRACT

Creutzfeldt-Jakob disease is a low incidence progressive neurodegenerative disorder and, meanwhile, the most frequent human prion disease. We report here the case of a 65 years old female with a 2-month history of rapidly progressive dementia. The clinical examination identified patent cerebellar and extrapyramidal signs. Despite the absence of myoclonic jerks and pathological findings in T2 and FLAIR MRI, the presence of protein 14-3-3 in a significant amount in cerebrospinal fluid (CSF) was identified. The patient succumbed to the illness within 2 month of hospitalization.

Keywords: sporadic Creutzfeldt-Jakob; rapidly progressive dementia, 14-3-3

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A PARKINSON’S DISEASE PATIENT TREATED WITH DEEP BRAIN STIMULATION, WITH IMPLANTATION AND REIMPLANTATION OF THE SYSTEM – AN 8 YEARS FOLLOW-UP

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Romanian Journal of Neurology, Volume XIII, No. 2, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

A PARKINSON’S DISEASE PATIENT TREATED WITH DEEP BRAIN STIMULATION, WITH IMPLANTATION AND REIMPLANTATION OF THE SYSTEM – AN 8 YEARS FOLLOW-UP

Gratiela Giurea-Neacsu, Amalia Ene, Bianca Nitu, Gabriel Iacob, Cornel Tudor, Paul Patrascu, Ovidiu Bajenaru and Bogdan O. Popescu

ABSTRACT

Deep brain stimulation is the most used neurosurgical procedure for advanced Parkinson’s disease. This procedure improves motor symptoms and some non-motor symptoms over a long period of time. In rare cases there are several complications which might lead to system removal. We report here a case were removal of the stimulation system was prompted by a scalp infection which extended to the subcutaneous fatty tissue and subcutaneous wire trajectories and did not resolved with antibiotics. The symptomatology worsened after device removal and reimplantation was decided. We followed this patient for 8 years after the first implant (6 years after the second implant) and he still has a good quality of live, being completely independent in most daily tasks.

Keywords: Parkinson disease, deep brain stimulation

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ADVANCED ATHEROSCLEROSIS AND STROKE IN A YOUNG PATIENT WITH CUTANEOUS LYMPHOMA

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Romanian Journal of Neurology, Volume XIII, No. 2, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

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ADVANCED ATHEROSCLEROSIS AND STROKE IN A YOUNG PATIENT WITH CUTANEOUS LYMPHOMA

Zela Cofoian-Amet, Cristina Mitu, Elena Rosianu, Ayghiul Mujdaba-Elmi and Bogdan O. Popescu

ABSTRACT

Atherosclerosis might begin in childhood with the development of fatty streaks. However, the advanced lesions of atherosclerosis, which complicate with ischemic events, are frequent rather in the elderly. We report here a case of early severe and symptomatic atheromatosis of large cervical vessels, in a young patient with some risk factors and strong familial history of vascular disease who was diagnosed with Sezary syndrome.

Keywords: atherosclerosis, stroke, cutaneous lymphoma, young adult

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