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Cristian Dinu Popescu

Latest posts by Cristian Dinu Popescu (see all)

  • STATE OF THE ART AND EFFICIENCY OF ROBOTIC THERAPY IN UPPER LIMB REHABILITATION – A LITERATURE REVIEW - 20/01/2016
  • BRAINSTEM AUDITORY EVOKED POTENTIALS IN PARKINSON’S DISEASE - 07/01/2016
  • BRAINSTEM AUDITORY EVOKED POTENTIALS FINDINGS IN ANKYLOSING SPONDYLITIS - 19/11/2015

Articles signed on Romanian Journal of NEUROLOGY:

STATE OF THE ART AND EFFICIENCY OF ROBOTIC THERAPY IN UPPER LIMB REHABILITATION – A LITERATURE REVIEW

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Romanian Journal of Neurology, Volume XIV, No. 4, 2015
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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ICMJE- Recommendations

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Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

STATE OF THE ART AND EFFICIENCY OF ROBOTIC THERAPY IN UPPER LIMB REHABILITATION – A LITERATURE REVIEW

Alexandru-Valer Grigoras, Bogdan Ignat, Marian Poboroniuc, Dragos Popescu and Cristian Dinu Popescu

ABSTRACT

Stroke represents the main cause of disability in adults. The disability is caused by motor or sensitive impairment, loss of interjoint coordination, spasticity and pathological synergies that occur after stroke. The new directions in motor rehabilitation point at facilitating neuroplasticity by multimodal stimulation, like virtual reality, or by active assistance in task specific training, like rehabilitation robots associated or not with functional electrical stimulation (FES). The aim of this article is, on one hand, to analize the way in which the existing robots face the biomechanical chalenges of modeling the upper limb's movements and, on the other hand, to evaluate the efficiency of robotics in rehabilitation, by pointing out the results of the existing clinical trials. Finally, possible directions for future research are discussed.

Keywords: rehabilitation robotics, exoskeleton, stroke, upper limb, rehabilitation

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BRAINSTEM AUDITORY EVOKED POTENTIALS IN PARKINSON’S DISEASE

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Romanian Journal of Neurology, Volume XII, No. 4, 2013
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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DOI - Crossref
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DOAJ
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HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

BRAINSTEM AUDITORY EVOKED POTENTIALS IN PARKINSON’S DISEASE

Daniel Alexa, Laura Alexa, Livia Popa, Dan Nicolae Paduraru, Bogdan Ignat, Aurora Constantinescu, Doru Baltag, Alexandrina Rotar and Cristian Dinu Popescu

ABSTRACT

Background. Parkinson’s disease is a neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra, but also in other dopaminergic and nondopaminergic areas of the brain and mainly in the brainstem. Auditory evoked potentials are routinely used in clinical practice to evaluate the function of the auditory nerve and auditory pathways in the brainstem. The aim of this study was to investigate the auditory brainstem pathways in patients with Parkinson disease.

Materials and methods. In this study was included 34 patients with Parkinson’s disease. The control group was composed of 29 healthy age- and sex-matched subjects. Detailed examination were performed in all individuals and the parkinsonian patients were stage between 2 and 4 according to Hoehn and Yahr’s classication. Recordings of BAEPs were performed with Nihon Kohden Neuropack using 80 dB HL alternating polarity clicks in each ear at a rate of 10 s-1.. Averaged potentials to 1,000 clicks were obtained.

Results. The BAEP results were interpreted for the latencies of waves I, II, III, IV, V and Interpeak Latencies (IPL) I-III, III-V and I-V. The results of our study have shown that the waves II, III, IV, V and IPL III-V were significantly delayed bilaterally. This modifications does not correlates with the age or duration of disease

Conclusion. This study showed some modifications of auditory evoked potentials wich can be determined by the neurodegenerative process that affects the brainstem.

Keywords: Parkinson disease, auditory evoked potentials, auditory pathways

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BRAINSTEM AUDITORY EVOKED POTENTIALS FINDINGS IN ANKYLOSING SPONDYLITIS

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Romanian Journal of Neurology, Volume XIV, No. 3, 2015
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexed

DOI - Crossref
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HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

BRAINSTEM AUDITORY EVOKED POTENTIALS FINDINGS IN ANKYLOSING SPONDYLITIS

Iulia Georgiana Stamate, Daniela Marilena Trofin, Elena Rezus and Cristian Dinu Popescu

ABSTRACT

Background. Ankylosing spondylitis (AS) is a chronic inflammatory potentially debilitating disease predominantly affecting the axial skeleton. A few intermittently published studies and research have proved the existence of some not yet explained neurophysiologic abnormalities in patients with AS.
Objectives. The aim of this study was to investigate the brainstem auditory evoked potentials and its relation with clinical findings, laboratory tests and pharmacological therapy used in patients with AS.
Material and method. Thirty-nine patients with AS were included in the study. The control group was composed of 50 healthy subjects. BAEP were recorded for all subjects. Patients were assessed by clinical specific tests, in- flammatory laboratory tests, Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and type of pharmacological therapy.
Results. The results have shown differences between the control group and the patients with AS in most of the wave latencies. Correlations Schober test, Ott index, chest expansion measurement and BASDAI were significant for some waves. CRP seems to be more valuable than ESR as a possible marker for neurologic subclinical involvement. Axial AS is more likely to be associated with BAEP abnormalities. There were also differences between the group with TNF alpha blockers therapy comparative with the group with other therapies.
Conclusions. This study highlights some abnormalities of BAEP in patients with AS. Diagnosis of multiple sclerosis or demyelination due to administration of TNF alpha blockers should be excluded in medical practice. Collaboration between neurologists and rheumatologists should be considered in monitoring AS patients.

Keywords: ankylosing spondylitis, auditory evoked potentials, TNF-alpha blockers, subclinical neurologic involvement

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ANKYLOSING SPONDYLITIS AND MULTIPLE SCLEROSIS: A SURPRISING PARALLEL

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Romanian Journal of Neurology, Volume XIII, No. 3, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ANKYLOSING SPONDYLITIS AND MULTIPLE SCLEROSIS: A SURPRISING PARALLEL

Iulia Georgiana Stamate, Daniel Alexa, Bogdan Ignat and Cristian Dinu Popescu

ABSTRACT

Ankylosing Spondylitis (AS) and Multiple Sclerosis (MS) are two different chronic autoimmune and inflammatory diseases, one rheumatic and the other one neurological, apparently without any connection between them. Yet a few case reports proved that AS may be associated with MS and this situation should be considered in some epidemiological environment.

Although the geographic map of incidence is approximately superposed for both entities there are only a few cases of association. Recent studies revealed that most loci associated with MS are located very close to or even within genes encoding molecules involved in immune system function, confirming the hypothesis that MS is a disease with immunologic mechanism. In addition, some of these loci are also associated at least with another autoimmune disease, thus reinforcing the idea that autoimmune diseases may have a common origin.

If MS is more common in patients with AS than in the general population, we can speculate the existence of common factors involved in these diseases. Because of the limited number of cases that associated these two diseases, the correct diagnosis of both entities considered separately or together becomes mandatory especially reflecting on the anti-TNFα agents used to treat AS which may exacerbate or induce a latent MS or demyelination processes in the central nervous system. In terms of pathogenic mechanisms, they are poorly known in both diseases, but each is characterized by an initial immune and inflammatory attack, in MS the target is the myelin sheath and in AS the enthesis tissue. A case with association between the two diseases raises important issues in choosing an appropriate treatment.

Keywords: ankylosing spondylitis, multiple sclerosis, autoimmune disease, TNFα

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SOCIO-ECONOMIC ISSUES IN ALZHEIMER’S DISEASE. RESILIENCE AND ALZHEIMER’S DISEASE CAREGIVERS

SELECT ISSUE

Romanian Journal of Neurology, Volume XIII, No. 4, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

SOCIO-ECONOMIC ISSUES IN ALZHEIMER’S DISEASE. RESILIENCE AND ALZHEIMER’S DISEASE CAREGIVERS

Cristian Dinu Popescu, Dan Trofin, Daniela Trofin, Daniel Alexa, Romeo Dobrin, Bogdan Ignat, Ioan Buraga and Daniela Matei

ABSTRACT

Alzheimer’s Disease (AD) is the most common form of dementia in the old population, carrying a major negative influence upon society and caregivers, as its socio-economic implications are enormous. The devastating impact of AD is also due to the fact that the diagnosis is difficult to be established in an early stage, and in spite of the advances made in medicine, the new symptomatic and disease modifying therapies have still only a mild though promising positive effect. Caregivers are exposed to increased risk of disease themselves, due to the high burden which predisposes them to stress related psychological, behavioral or cognitive disorders. Greater caregiver resilience can predict lower levels of depression. Also a strong external support system was associated with increased resilience. Establishing a pattern for the behavioral and psychological manifestations in dementia can have as direct effect developing better coping strategies in order to reduce stress and the burden of the caregivers.

Some data regarding the economic and social impact of AD, as well as facts and numbers from our local centers will be described in the following pages.

Keywords: dementia, Alzheimer’s Disease, social, economics, caregiver, burden

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