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THE EFFECT OF ERYTHROPOIETIN ON MAGNESIUM DURING ISCHEMIA REPERFUSION INJURY IN RATS
C. Tsompos, C. Panoulis, K. Toutouzas, G. Zografos and A. Papalois
The aim of this experiment study was the erythropoietin testing, on rat model and particularly on ischemia reperfusion protocol. The benefit or the non effect of that molecule was studied biochemically on blood magnesium.
Material and methods 40 rats were used of mean weight 247.7 g. Magnesum was measured on these time points: on 60 min after reperfusion (groups A and C), and on 120 min after reperfusion (groups B and D), A and B without but C and D with erythropoietin administration.
Results were that 1) erythropoietin administration decreased non significantly the magnesium by 0.035 mg/dl (-0.2453171 mg/dl - 0.1753171 mg/dl) (P = 0.7381), in accordance also with paired t-test (P = 0.7116), 2) reperfusion time increased non significantly the magnesium by 0.135 mg/dl (-0.0709124 mg/dl - 0.3409124 mg/dl) (P = 0.1924), in accordance also with paired t-test (P = 0.1665), and 3) interaction of erythropoietin administration and reperfusion time decreased non significantly the magnesium levels by 0.0063636 mg/dl (-0.1333617 mg/dl - 0.1206344 mg/dl) (P = 0.9197).
Conclusions are that erythropoietin administration, reperfusion time and their interaction have miscellaneous and not significant effects on magnesium within short-term context of 2 hours. Perhaps, a longer study time may reveal some significant effect.
Keywords: erythropoietin, magnesium, reperfusion