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Zoltan Bajko

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Articles signed on Romanian Journal of NEUROLOGY:

CORRELATIONS BETWEEN THE SEVERITY OF CARDIOVASCULAR AUTONOMIC NEUROPATHY AND OTHER COMPLICATIONS IN TYPE 2 DIABETES MELLITUS

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Romanian Journal of Neurology, Volume XV, No. 1, 2016
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexată BDI  |  IDB Indexed

DOAJ
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Scopus
DOI - Crossref

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Tema plagiatului este tot mai mult discutată în ultima vreme. Apariția unor programe performante de căutare și identificare a similitudinilor între texte [...]

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CORRELATIONS BETWEEN THE SEVERITY OF CARDIOVASCULAR AUTONOMIC NEUROPATHY AND OTHER COMPLICATIONS IN TYPE 2 DIABETES MELLITUS

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ABSTRACT

Introduction. Cardiovascular Autonomic Neuropathy (CAN), also known as the “silent killer”, represents a serious complication of diabetes mellitus and is most of the times ignored. This is a highly topical issue, given the increased number of patients diagnosed with type 2 diabetes mellitus (T2DM). The purpose of this study was to determine the association between the severity of CAN and the severity of other microvascular complications, such as diabetic sensory-motor polyneuropathy (DSMP), diabetic retinopathy (DR) and macrovascular complications (carotid and peripheral vascular atherosclerosis) in patients with T2DM.

Methods. A total of 149 patients with T2DM were assessed for CAN using the Ewing’s battery of cardiovascular autonomic function tests. The patients were evaluated for diabetic microvascular complications (DSMP, RD), respectively macrovascular complications (carotid atherosclerosis by intima media thickness and peripheral vascular atherosclerosis by ankle-brachial index).

Results. Of the 45 patients with intermediate CAN, 35.55% were without DR, 51.11% had non-proliferative DR and 13.33% had proliferative DR. From the 13 patients with severe CAN, 76.92% had non-proliferative DR and 23.07% had proliferative DR. From the 56 patients with subclinical CAN, 26.7% had no DSMP, 48.2% had subclinical DSMP and 25% had clinical DSMP. Of the 45 patients with intermediate CAN, 11.2% had subclinical DSMP and 80% had clinical DSMP. 

Conclusion. In T2DM we demonstrated that an increase in the severity of cardiovascular autonomic injury is associated with an increase in the prevalence and severity of DSMP and DR, respectively carotid and peripheral atherosclerosis.

Keywords: cardiovascular autonomic neuropathy, type 2 diabetes mellitus, microvascular and macrovascular complications

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SUBCLAVIAN DOUBLE STEAL SYNDROME PRESENTING WITH COGNITIVE IMPAIRMENT AND DIZZINESS

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Romanian Journal of Neurology, Volume XIII, No. 3, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexată BDI  |  IDB Indexed

DOAJ
Ebsco Host - Medline
Scopus
DOI - Crossref

HIGHLIGHTS

Plagiatul – în actualitate

Tema plagiatului este tot mai mult discutată în ultima vreme. Apariția unor programe performante de căutare și identificare a similitudinilor între texte [...]

Committe on Publication Ethics

A forum for responsible and ethical research publishing – Code of Conduct and Best Practice Guidelines for Journal Editors.

SUBCLAVIAN DOUBLE STEAL SYNDROME PRESENTING WITH COGNITIVE IMPAIRMENT AND DIZZINESS

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ABSTRACT

Background. Atherosclerotic occlusion of the brachiocephalic artery is a very rare condition resulting in a distinctive pattern of hemodynamic disturbances in the cerebral circulation described as subclavian double steal syndrome.

Case report. We present the case of a 66-year-old male patient with atherosclerotic occlusion of the brachiocephalic artery with double steal syndrome presenting with cognitive impairment and dizziness. The diagnosis was based on duplex ultrasound examination and was confirmed with angiography. The patient was referred for revascularisation surgery, with extra-anatomical bypass. The outcome was favorable regarding the vertebrobasilar symptomatology, but mild cognitive impairment persisted.

Keywords: subclavian double steal syndrome, brachiocephalic artery occlusion, cognitive impairment, dizziness

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THE DUAL ROLE OF TRANSFORMING GROWTH FACTOR BETA IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS AND EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

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Romanian Journal of Neurology, Volume XIII, No. 3, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexată BDI  |  IDB Indexed

DOAJ
Ebsco Host - Medline
Scopus
DOI - Crossref

HIGHLIGHTS

Plagiatul – în actualitate

Tema plagiatului este tot mai mult discutată în ultima vreme. Apariția unor programe performante de căutare și identificare a similitudinilor între texte [...]

Committe on Publication Ethics

A forum for responsible and ethical research publishing – Code of Conduct and Best Practice Guidelines for Journal Editors.

THE DUAL ROLE OF TRANSFORMING GROWTH FACTOR BETA IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS AND EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

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ABSTRACT

Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that is involved in numerous pathological processes. TGF-β functions in the immune system are to perform the regulation of lymphocyte differentiation, survival and destruction. In autoimmune diseases of the central nervous system, like multiple sclerosis (MS) and the animal model of experimental autoimmune encephalomyelitis (EAE), depending on the context, TGF-β has paradoxically pro- and anti-inflammatory effects, explaining the difficulties in creating therapeutic strategies targeting TGF-β. This review presents the progresses that have been made on the understanding of TGF-β in the pathogenesis of both EAE and MS.

Keywords: transforming growth factor beta, multiple sclerosis, experimental autoimmune encephalomyelitis, pathogenesis

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DEPRESSION IN MULTIPLE SCLEROSIS – REVIEW

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Romanian Journal of Neurology, Volume XIV, No. 1, 2015
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexată BDI  |  IDB Indexed

DOAJ
Ebsco Host - Medline
Scopus
DOI - Crossref

HIGHLIGHTS

Plagiatul – în actualitate

Tema plagiatului este tot mai mult discutată în ultima vreme. Apariția unor programe performante de căutare și identificare a similitudinilor între texte [...]

Committe on Publication Ethics

A forum for responsible and ethical research publishing – Code of Conduct and Best Practice Guidelines for Journal Editors.

DEPRESSION IN MULTIPLE SCLEROSIS – REVIEW

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ABSTRACT

Depression is one of the most important psychiatric comorbidity in multiple sclerosis and is associated with increased disability and poor quality of life. The diagnosis is challenging because of the overlapping symptomatology. The pathogenesis is complex and controversial, the incidence is high, but is frequently under-diagnosed and under-treated.

The aim of this article is to review the most important aspects of depression in multiple sclerosis as: epidemiology, pathogenesis, assessment, correlates with disability, cognition, fatique, quality of life, suicide, the relationship with the immunomodulatory therapy, neuroimaging and treatment options.

Keywords: multiple sclerosis, depression

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