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Ovidiu Alexandru Bajenaru

Latest posts by Ovidiu Alexandru Bajenaru (see all)

  • CAN WE PREDICT THE RESPONSE TO GALANTAMINE IN ALZHEIMER`S DISEASE PATIENTS? - 19/11/2015
  • PREVALENCE OF NON-MOTOR SYMPTOMS IN PARKINSON’S DISEASE – AN OBSERVATIONAL STUDY - 15/09/2015

Articles signed on Romanian Journal of NEUROLOGY:

CAN WE PREDICT THE RESPONSE TO GALANTAMINE IN ALZHEIMER`S DISEASE PATIENTS?

SELECT ISSUE

Romanian Journal of Neurology, Volume XIV, No. 3, 2015
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexată BDI  |  IDB Indexed

DOAJ
Ebsco Host - Medline
Scopus
DOI - Crossref

HIGHLIGHTS

Plagiatul – în actualitate

Tema plagiatului este tot mai mult discutată în ultima vreme. Apariția unor programe performante de căutare și identificare a similitudinilor între texte [...]

Committe on Publication Ethics

A forum for responsible and ethical research publishing – Code of Conduct and Best Practice Guidelines for Journal Editors.

CAN WE PREDICT THE RESPONSE TO GALANTAMINE IN ALZHEIMER`S DISEASE PATIENTS?

Carmen Gavan, Cristina Tiu and Ovidiu Alexandru Bajenaru

ABSTRACT

Although considerate progress was obtained by adding imagistic and laboratory test, clinical examination remains the core of the diagnosis for Alzheimer`s disease. After 20 years of experience with anticholinergic drugs we know that only one third of the patients respond to the treatment; the treatment is more efficient in the initial stages of the neurocognitive decline. It is important to evaluate the efficacy of drugs as soon as possible. We examined patients with mild and moderate Alzheimer`s disease referred through our outpatient clinic. They fulfilled the NINCDS-ADRDA criteria for Alzheimer`s disease and they scored at baseline 21 to 26 points on MMSE. The patients were treated with Galantamine, 8 mg/day for the first month and then 16 mg/day. We evaluated the patients after 2 and 6 months of treatment; we performed MMSE and ADAS-Cog in order to see if a more complex evaluation would be helpful. We considered that the treatment was efficient if MMSE score did not decrease after 6 months of treatment. We also evaluated clinical disability using DAD (Disability Assessment for Dementia Scale) and the difficulty of living with a patient with dementia using CBS (Caregiver Burden Scale). The examination using MMSE and ADAS-Cog after two months of treatment does not have a predictable value. ADAS-Cog examination can be useful for patients that have a stable MMSE score after six months of treatment. Although the evolution of ADAS-Cog and MMSE scores were significantly positive, clinical disability of the patients progressed, rising concerns for their caregivers.

Keywords: Alzheimer`s disease, MMSE, ADAS-Cog, DAD, CBS, galantamine

Full text | PDF

PREVALENCE OF NON-MOTOR SYMPTOMS IN PARKINSON’S DISEASE – AN OBSERVATIONAL STUDY

SELECT ISSUE

Romanian Journal of Neurology, Volume XIII, No. 3, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexată BDI  |  IDB Indexed

DOAJ
Ebsco Host - Medline
Scopus
DOI - Crossref

HIGHLIGHTS

Plagiatul – în actualitate

Tema plagiatului este tot mai mult discutată în ultima vreme. Apariția unor programe performante de căutare și identificare a similitudinilor între texte [...]

Committe on Publication Ethics

A forum for responsible and ethical research publishing – Code of Conduct and Best Practice Guidelines for Journal Editors.

PREVALENCE OF NON-MOTOR SYMPTOMS IN PARKINSON’S DISEASE – AN OBSERVATIONAL STUDY

Titus Mihai Vasile, Adina Maria Roceanu, Florina Antochi and Ovidiu Alexandru Bajenaru

ABSTRACT

Objectives. This study aim is to evaluate the prevalence of non-motor symptoms in Parkinson’s disease

Methodology. We conducted an observational study in a prospective approach on a cohort of 70 patients admitted with a diagnosis of Parkinson’s disease in the Neurology Department of the University Emergency Hospital Bucharest for pre-surgery assessment or referred for a consultation to the Outpatient Department of Neurology of the Central Military Emergency Hospital, “Carol Davila” in the last two quarters of 2007, using a technique based on questionnaire (NMSQuest).

Results. Patients included in this study were generally elderly, with a long relative history of disease. They are mostly in the moderate stage of disease and used treatment regimens with combinations of drugs. Prevalence of some non-motor symptoms according to the answers of patients in NMS questionnaire (NMSQuest), like: depression, memory impairment sleep disturbances, sexual disturbances, „light head”, constipation was statistically significant high in our group of patients.

Conclusions. Non-Motor Questionnaire (NMSQuest) can be a useful clinically tool for detecting the common nonmotor symptoms in patients with Parkinson’s disease. Prevalence of non-motor symptoms in Parkinson’s disease is high and require further evaluation of their impact on patient’s quality of life.

Keywords: Parkinson disease, non-motor symptoms, prevalence, NMSQuest

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