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Corina Ursu

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Articles signed on Romanian Journal of NEUROLOGY:

EVALUATION OF VASOMOTOR RESPONSE IN OPHTHALMIC MIGRAINE PATIENTS

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Romanian Journal of Neurology, Volume XV, No. 2, 2016
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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EVALUATION OF VASOMOTOR RESPONSE IN OPHTHALMIC MIGRAINE PATIENTS

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ABSTRACT

Introduction. Hemodynamic changes of the cerebral arteries in ophthalmic migraine may be an important pathophysiological mechanism of the disease. The nitric oxide (NO) synthesis plays a significant role in hemodynamic changes due to vasodilatation effect. The purpose of this study is to evaluate the possible hemodynamic changes by Doppler measurements and their correlation with NO synthesis in ophthalmic migraine.
Method. 37 ophthalmic migraine patients were compared with 35 healthy volunteers. Other cerebral and ophthalmic diseases were excluded by ophthalmological, neurological, and cranial MRI examinations. The migraine assessment scale (MIDAS) was used for clinical evaluation. Transcranial Doppler ultrasonography (TCD) was performed using 2 and 4 MHz frequencies transducers. The flow velocities of the internal carotid artery, middle cerebral artery, posterior cerebral artery, and NO plasma concentration were assessed 2 hours after migraine attacks.
Results. The NO synthesis was significantly increased compared to the control group. The flow velocities decreased in internal carotid artery, middle cerebral artery, and posterior cerebral artery. The correlation between decreased flow velocities and NO plasma concentration was significant.
Conclusions. Autonomic nervous system dysfunction in ophthalmic migraine is an important pathophysiological mechanism. The flow velocity status may reflect the vasomotor response and endothelial reactivity induced by NO synthesis. Further studies on the vasomotor response are necessary for the evaluation of this pathophysiological mechanism implication in ophthalmic migraine.

Keywords: migraine, nitric oxide, transcranial Doppler ultrasonography

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VISUAL PATHWAYS INVOLVEMENT IN MULTIPLE SCLEROSIS FROM PATHOLOGICAL PROCESS TO NEURO-OPHTHALMOLOGIC ASSESSMENT

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Romanian Journal of Neurology, Volume XIII, No. 2, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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DOI - Crossref
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DOAJ
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Ebsco Host - Medline
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ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

VISUAL PATHWAYS INVOLVEMENT IN MULTIPLE SCLEROSIS FROM PATHOLOGICAL PROCESS TO NEURO-OPHTHALMOLOGIC ASSESSMENT

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ABSTRACT

Multiple sclerosis (MS) is a demyelinating disease associated with a myriad of visual pathways pathology. These pathologies need to be assessed, even when asymptomatic, because they may represent an important index of disease course, severity and treatment response. This is a review of the importance of different visual pathways assessment methods such as classic ophthalmologic examination, cerebrospinal fluid analysis, Doppler ultrasonography of the orbital vessels, magnetic resonance imaging, optical coherence tomography, visual evoked potential, evaluating which may contribute to elucidate the pathophysiological process, structural and functional damage. The modern medical technology developed multiple methods which are trying to link their results to the overall brain damage in MS. A global analysis of these methods is needed, in order to a better evaluation of visual pathways damage associated with multiple sclerosis.

Keywords: multiple sclerosis, visual pathways, optical coherence tomography, visual evoked potentials

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CORRELATION BETWEEN MIGRAINE SEVERITY AND COMORBIDITIES IN EPISODIC MIGRAINE PATIENTS

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Romanian Journal of Neurology, Volume XIV, No. 2, 2015
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

CORRELATION BETWEEN MIGRAINE SEVERITY AND COMORBIDITIES IN EPISODIC MIGRAINE PATIENTS

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ABSTRACT

Introduction. Migraine is an important cause of disability that affects the quality of life producing a substantial social impairment.

Objectives. The aim of this study was to evaluate the correlation between migraine severity and comorbidities in patients with episodic migraine.

Methods. 2 groups of patients were included in the study: group 1 – control group (healthy subjects, n = 50), and group 2 – study group (patients with episodic migraine attacks, n = 65). Both groups were assessed for nonmodifiable risk factors (age), and modifiable risk factors: BMI (body mass index), lipids profiles (LDL-cholesterol, HDL-cholesterol, triglycerides), inflammatory parameters (C reactive protein and fi brinogen), and endothelial dysfunction (nitric oxide synthesis expressed as NOx). The migraine was diagnosed according to ICHD-2 (International Classification of Headache Disorders) and the severity was evaluated by MIDAS (Migraine Disability Assessment Scale). The study group was compared with control group. The parameters that showed statistic significance were correlated with MIDAS scale.

Results. There was a significant correlation between the severity and frequency of migraine attacks (evaluated by MIDAS scale) and BMI. The subgroup with higher inflammatory parameters and decreased NOx had an increased MIDAS score.

Conclusions. The connection between obesity, inflammatory parameters and migraine may be useful for new prophylaxis potent therapies. The individual personalized therapies according with particular risk factors of each patient may be a chance for better results. Identification and control of risk factors in migraine patients may be particularly important.

Keywords: migraine, risk factors, obesity, inflammation

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