SELECT ISSUE

Romanian Journal of Neurology, Volume XIII, No. 3, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148

Indexed in / abstracted by

Embase
Scopus Cross-ref
Index Copernicus
Ulrichs Ebsco Host
Medline - Ebsco PubMed

HIGHLIGHTS

Plagiatul – in actualitate

Tema plagiatului este tot mai mult discutata in ultima vreme. Aparitia unor programe performante de cautare si identificare a similitudinilor intre texte [...]

Committe on Publication Ethics

A forum for responsible and ethical research publishing – Code of Conduct and Best Practice Guidelines for Journal Editors.

THE DUAL ROLE OF TRANSFORMING GROWTH FACTOR BETA IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS AND EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

, , and

ABSTRACT

Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that is involved in numerous pathological processes. TGF-β functions in the immune system are to perform the regulation of lymphocyte differentiation, survival and destruction. In autoimmune diseases of the central nervous system, like multiple sclerosis (MS) and the animal model of experimental autoimmune encephalomyelitis (EAE), depending on the context, TGF-β has paradoxically pro- and anti-inflammatory effects, explaining the difficulties in creating therapeutic strategies targeting TGF-β. This review presents the progresses that have been made on the understanding of TGF-β in the pathogenesis of both EAE and MS.

Keywords: transforming growth factor beta, multiple sclerosis, experimental autoimmune encephalomyelitis, pathogenesis

Full text | PDF