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Raluca Ioana Teleanu

Latest posts by Raluca Ioana Teleanu (see all)

  • A PERMANENT NEUROSURGICAL CHALLENGE: LOW GRADE GLIOMAS - 27/01/2017
  • ANTI-MUSK ANTIBODY POSITIVE MYASTHENIA GRAVIS WITH CHILDHOOD ONSET - 21/10/2016
  • LHERMITTE-DUCLOS DISEASE ASSOCIATED WITH MENINGIOMA – A RARE CASE - 15/09/2015

Articles signed on Romanian Journal of NEUROLOGY:

A PERMANENT NEUROSURGICAL CHALLENGE: LOW GRADE GLIOMAS

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Romanian Journal of Neurology, Volume XV, No. 4, 2016
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

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Promoting Global Health

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A PERMANENT NEUROSURGICAL CHALLENGE: LOW GRADE GLIOMAS

Daniel Mihai Teleanu, Nicolae-Stefan Bogaciu, Andreea Marinescu, Raluca Ioana Teleanu and Adrian Balasa

ABSTRACT

Introduction. The utilization of Magnetic Resonance Spectroscopy (MRS) brings an important piece of information to an overall MR study, thus aiding the physician in making an accurate assumption regarding the histological grade of a tumor. The purpose of this study is to verify the reliability of MRS in correctly diagnosing both the nature of tumors and their grade.
Material and methods. This is an observational study that was conducted from January 2011 to June 2016 on 49 patients confirmed to be low-grade gliomas (LGG) by pathological examination, who were admitted in our Neurosurgery Department in this period. Both retrospective and prospective data were collected. Inclusion criteria comprise unique tumoral lesion at the moment of diagnosis, follow-up for at least one year. Exclusion criteria included: other types of tumors with any location, patient refusal to undergo histopathological examination of the resected tissue, uncompliant and non-collaborating patients. Of all patients, 22 were subjected to an MRS study which suggested the presence of a low-grade glioma subsequently confirmed by the pathological examination.
Results. MRS has been shown to provide accurate non-invasive diagnosis of LGG’s, by analyzing the concentration of metabolites inside the lesions which tend to be specific for these tumours: relatively elevated levels of N-acetylaspartate and creatine with reduced levels in the concentration of choline and absent lipids and lactate. It has also been observed that pre-operative MRS assists the physician in selecting the optimal place for biopsy, so that the pathological examination provides conclusive results.
Conclusions. With the increased availability of MRI technology, MRS comes as a milestone in the advancement of more accurate and patient-friendly methods of diagnostic for pathologies as LGG’s which constitute a permanent challenge for neurosurgeons. The results of this study underlines the importance of MRS as a method for follow up patients with LGG, but cannot replace the need for obtaining bioptic tissue for pathological examination, especially after the new grading system of WHO, which was published in June 2016. This new grading system takes into account the molecular biology in predicting the natural history of cerebral tumours.

Keywords: magnetic resonance spectroscopy, low grade glioma, management, biopsy

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ANTI-MUSK ANTIBODY POSITIVE MYASTHENIA GRAVIS WITH CHILDHOOD ONSET

SELECT ISSUE

Romanian Journal of Neurology, Volume XV, No. 2, 2016
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ANTI-MUSK ANTIBODY POSITIVE MYASTHENIA GRAVIS WITH CHILDHOOD ONSET

Diana Epure, Smaranda Nita and Raluca Ioana Teleanu

ABSTRACT

Myasthenic syndromes are acquired diseases which unite the impairment of neuromuscular transmission with associated muscle weakness, occasional positive anti-acetylcholine or MuSK antibodies and characteristic electrodiagnostic features. We present the case of a ten year old girl with ocular muscle weakness at onset and positive anti-MuSK antibodies, with a favorable evolution under pyridostigmine bromide.

Keywords: myasthenia, MuSK, acetylcholine, pyridostigmine, child

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LHERMITTE-DUCLOS DISEASE ASSOCIATED WITH MENINGIOMA – A RARE CASE

SELECT ISSUE

Romanian Journal of Neurology, Volume XIII, No. 4, 2014
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148
DOI: 10.37897/RJN

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

LHERMITTE-DUCLOS DISEASE ASSOCIATED WITH MENINGIOMA – A RARE CASE

Daniel Mihai Teleanu, Cornel Tudor and Raluca Ioana Teleanu

ABSTRACT

Lhermitte-Duclos disease (LDD), also known as dysplastic gangliocytoma of the cerebellum is a benign disease, extremely rare, characterized by loss of normal cerebellar cortical architecture and focal thickening of the folia. Lhermitte-Duclos disease as a major CNS manifestation of Cowden disease is a rare condition. The association between Lhermitte-Duclos disease and meningioma is even more rare, only few cases having been documented in the literature. We present a very rare case of a 53-year-old woman who was admitted in our department for recurrent episodes of headache and epilepsy. Magnetic resonance imaging revealed the presence of a well-defined lesion with an abnormal laminated pattern of cortical architecture involving most of the right cerebellar hemisphere, compressing the fourth ventricle and also a meningioma. Complete removal of the meningioma and partial removal of the cerebellar lesion was performed and histopathological exam confirmed Lhermitte-Duclos disease.

Keywords: Lhermitte Duclos disease, meningioma

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