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Romanian Journal of Neurology, Volume XIV, No. 1, 2015
ISSN 1843-8148  |  e-ISSN 2069-6094
ISSN-L 1843-8148

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THE EFFECT OF THE ANTIOXIDANT DRUG “U-74389G” ON TOTAL PROTEIN LEVELS DURING ISCHEMIA REPERFUSION INJURY IN RATS

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ABSTRACT

The aim of this experimental study was to examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in an ischemia – reperfusion protocol. The beneficial effect or non-effectiveness of that molecule were studied biochemically using blood mean total protein levels.

Materials and methods. 40 rats of mean weight 231.875 gr were used in the study. Total protein levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D), A and B without but C and D with U-74389G administration.

Results were that U-74389G administration significantly decreased the predicted TP levels by 7.34% + 1.76% (P = 0.000). Reperfusion time non-significantly increased the predicted TP levels by 1.46% + 2.12% (p = 0.410). However, U-74389G administration and reperfusion time together significantly decreased the TP levels by 4.08% + 1.10% (P = 0.000).

Conclusions are that U-74389G administration interacted or not with reperfusion time significantly decreases the total protein levels.

Keywords: ischemia, U-74389G, total protein, reperfusion

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